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Lupus Symptoms: How to Identify

August 3rd, 2011 Leave a comment Go to comments

Lupus Symptoms– The best ways to Determine

Symptoms of Lupus

Systemic lupus erythematosus (SLE) is a chronic inflamed problem of unidentified cause that could have an effect on the joints, skin, heart, renal systems, nerves, lungs, serous membranes and/or other organs of the body, therefore, lupus symptoms are differ. SLE is characterized by cells and cell damages from pathogenic autoantibodies and immune complexes. Ninety percent of patients are women in childbearing years and the illness is a lot more common in African Americans. Multiple body organ system indications can take place, including musculoskeletal (arthralgias, myalgias), cutaneous (malar breakout, photosensitivity, hair loss), renal (nephritis, nephritic disorder), stressed (seizures, hassles), cardiopulmonary (pericarditis, pleuritis), hematologic (anemia, leukopenia). Immunologic problems, in particular the generation of a quantity of antinuclear antibodies, are another noteworthy attribute of the disorder. There are many kinds of lupus, Systemic lupus erythematosus which influences different physical body parts is the most typical kind, the others are Subacute Cutaneous lupus erythematosus – generates skin sores on components of the body subjected to the sunlight, Discoid lupus erythematosus – causes a skin rash that doesn’t go away entirely, Drug-induced lupus – could be induced by medications, Neonatal lupus – an uncommon type of lupus that impacts newborn babies.

The medical advancement of Wide spread lupus erythematosus is varied and can be represented by patterns of remissions and lasting or severe relapses. Ladies, primarily in their 20s and 30s, are had an effect on much more frequently than guys.

People with SLE are subject to a lot of symptoms, troubles, as well as inflamed participation that might have an impact on virtually every body organ. The most frequent pattern is a mix of constitutional problems with skin, medium hematologic, serologic involvement, in addition to musculoskeletal. On the other individual hand, a number of people have mainly kidney, hematologic, or central nerve fibers manifestations. The particular pattern that dominates through first couple of years of the disease is likely to control later.

Lupus Symptoms, Constitusional – 50 – 100 % of clients has fever, fatigue, and fat burning. Over 50 percent of lupus symptoms is fever that is believed to be because of active illness. 60 % of the fevers were thought to be due to lupus, 23 % to infection, and 17 % to various other reasons. Threat elements for infection: long-lasting disease damage, neutropenia, hypocomplementemia, lymphopenia, energetic lupus disease, renal participation, neuropsychiatric signs, and using glucocorticoids and other immunosuppressive drugs. A lot of fevers as a result of energetic SLE will certainly transmit with usage of acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), and/or low to medium dosages of corticosteroids, if it does not, the suspicion of a contagious or medicine associated etiology is risen.

Lupus symptoms in women

Low Energy or tiredness happens in 80 – 100 % of lupus symptoms, and often the most debilitating. Its existence in not obviously correlated with other measures of disease activity. Hence fatigue is highly correlated with reduced physical exercise tolerance. However, fatigue might not be caused by active SLE, yet to one or more of the following: depression, increased work load, poor habits (smoking, less active living, substance abuse), stress or anxiety, hypothyroidism, anemia, use of specific medications (such as beta-blockers, prednisone), any inflammatory and/or contagious disease, coexistent fibromyalgia, sleeping disturbances and/or deconditioning, or a perception of inadequate social support. Fatigue caused by SLE may respond to antimalarials and glucocorticoids.Weight gain in lupus is commonly caused by one of two factors: salt and water retention associated with hypoalbuminemia, or increased appetite associated with the use of glucocorticoids.Weight loss often occurs before the diagnosis of SLE. Unwilled weight loss could be because of decreased appetite, the side effects of drugs (especially diuretics or antimalarials), and gastrointestinal disease such as (GERD) gastroesophageal reflux disease, abdominal pain, pancreatitis, or peptic ulcer disease.

Here is a list of Lupus Symptoms 

General Symptoms : Photosensitivity (sensitive to the sun light), Fatigue, Malaise, Hair Loss, Weight gain or loss, Fever
Central Nervous System : Lupus Headaches, Fibromyalgia, CNS Vasculitis
Cardio-Vascular System : Antiphospolipid Syndrome, Anemia, Chest Pain when taking a deep breath, Myocarditis, Endocarditis
Gastrointestinal Tract : Gastroesophageal Reflux Disease, Lupus Hepatitis, Chronic Diarrhoea, Nausea and Vomitting, Ascites
Musculoskletal System : Arthritis, Muscle Pain, Fibromyalgia
Reproductive System : Lesion(s) in genital area, Loss of Libido, Increase Miscarriage rate
Kidney : Lupus Nephritis
Skin : Discoid Lupus Erytemathosus, Malar Rash / Butterfly Rash, Tumid Lupus Erythematosus, Raynaud’s Phenomenon, Lupus Panniculitis, Purpura, Subacute Cutaneus Lupus
Mouth and Nose : Mucosal Discoid Lupus, Mouth and Nose Ulcers, Bullous Systemic Lupus Erythematosus
Lungs : Pleuritis, Shortness of breath, Chest Pain
Other Organs : Eye Problem, Lupus Thyroiditis, Swollen Glands, Rhinitis nonallergica

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How Is Lupus Diagnosed?

Lupus is not diagnosed with single test only. The diagnosis might take several months or years, as your doctor has to piece together the puzzle of symptoms of this complex disease in order to be diagnosed accurately. Knowledge and awareness of  the doctor and also good communication from the patient are important so that the correct diagnosis can be made. Some test for lupus or tools may be required by your doctor to make the diagnosis of lupus, such as :

  • Medical history
  • Complete physical examination
  • Complete blood count (CBC)
  • Blood chemistries
  • Erythrocyte sedimentation rate (ESR)
  • Urinalysis
  • Complement levels
  • Antinuclear antibody test (ANA)
  • Other autoantibody tests (anti-DNA, anti-Sm, anti-RNP, anti-Ro [SSA], anti‑La [SSB])
  • Anticardiolipin antibody test
  • Skin biopsy (looking at skin samples under a microscope)
  • Kidney biopsy (looking at tissue from your kidney under a microscope).
  • X rays and other imaging tests can help doctors see the organs affected lupus

Criteria for classification of SLE
(SLE = 4 or more of these 11 criteria)

  • Malar (butterfly) rash
  • Discoid rash
  • Photosensitivity
  • Arthritis
  • Oraulcers
  • Serositis (pleurisy or pericarditis)
  • Renadisorders (proteinuria or casts)
  • Neurologicadisorders (intractable headache, seizures or psychosis)
  • Haematologicadisorders (haemolytic anaemia, leucopenia, lymphopenia or thrombocytopenia)
  • Immunologicadisorders (positive LE cells, anti-DNA, anti-Sm or false positive syphilis serology)
  • Positive antinuclear antibody

Diagnostic tests

  • ESR—elevated in proportion to disease activity
  • antinuclear antibodies (ANA)—positive in 95% (key test)
  • double stranded DNA antibodies—90% specific for SLE but present in only 60% (key test)
  • rheumatoid factor—positive in 50%
  • LE test—inefficient and not used

The diagnosis cannot be made on blood tests alone. Supportive clinicaevidence is necessary.

Management

Appropriate explanation, support and reassurance, use of sunscreens
Refer to consultant for shared care
Drug treatments

  • mild: NSAIDs (for arthralgia)
  • moderate (esp. skin, joint serosa involved): low-dose antimalarials, e.g.
  • hydroxychloroquine up to 6 mg/kg once daily
  • severe: corticosteroids are the mainstay immunosuppressive drugs, e.g. azathioprine

Avoid drugs in those in clinicaremission and with normacomplement levels
Other treatments such as plasma exchange and immunosuppressive regimens available for severe disease

 

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