Exactly what is Rheumatoid arthritis – Rheumatoid arthritis (RA) is among autoimmune ailments which is a chronic or long-term inflammatory problem. RA is the commonest chronic inflammatory polyarthritis and affects about 3 % of the populace. The symptoms create slowly, and could differ from a mild to a most extreme debilitating expression. It might consist of joint pain, tightness, and swelling. The condition can influence numerous cells throughout the body, yet the joints are typically most severely impacted. The cause of rheumatoid arthritis is unknown.
RHEUMATOID ARTHRITIS DANGER ELEMENTS – The particular reason for rheumatoid arthritis is still not understood yet. Sensitivity aspects and Launching elements, nonetheless, have been presumed as elements that can affect an individual’s danger.
Susceptibility factors— RA more than likely creates when a prone person is subjected to factors that begin the inflammatory process. Heredity, gender, and genes mostly figure out an individual’s possibility of developing rheumatoid arthritis. Around 1 per 100 individuals has actually rheumatoid arthritis.
- Heredity – RA is not a received disease. Genes do not trigger rheumatoid arthritis, they just affect the risk of illness’ advancement.
- Gender – Gender appears to take part in a major duty in an individual’s susceptibility to rheumatoid arthritis. Ladies are about 3 times more likely than males.
- Specific genes – Person with specific variants of human leukocyte antigen (HLA) genes are most likely to get rheumatoid arthritis.
Starting aspects – Many individuals who have HLA genes never ever create the condition. As a matter of fact, when one identical twin has rheumatoid arthritis signs, the probability that the other individual will certainly establish illness is just approximately 1 in 3. This shows that aspects must be essential for a person to establish RA.
- Infection – Bacteria or viruses could be just one of the elements that start rheumatoid arthritis.
- Smoking – Smoking might raise the risk of creating RA and also could enhance the probability the intensity need to it happens.
- Anxiety – Taxing occasions such as mishaps, separation and sorrow are more common in individuals with RA in the 6 months prior their diagnosis.
RHEUMATOID ARTHRITIS SYMPTOMS— In the majority of people RA starts with the perilous start of discomfort and stiffness of the little joints of the hands and feet which is on-going as opposed to short lived and mostly has an effect on the fingers where symmetrical participation of the PIP joints produces spindling while the metacarpophalangeal joints (joints in the center of the fingers) establish diffuse thickening as does the arm. Early symptoms could feature tiredness, muscle pain, a low-grade fever, fat burning, and numbness and tingling in the hands. Sometimes, these signs take place prior to joint discomfort or stiffness is obvious. In 25 % of cases Rheumatoid arthritis signs present as arthritis of a solitary joint such as the knee, a circumstance causing complication with Lyme illness or a spondyloarthropathy.
- Hands : MCP and PIP joints, DIP joints (30%)
- Wrist and elbows
- Feet : MTP joints, tarsal joints (not IP joints), ankle
- Knees (common) and hip (delayed—up to 50%)
- Shoulder (glenohumeral) joints
- Temporomandibular joints
- Cervical spine
Joint symptoms – These Rheumatoid Arthritis symptoms Usually begin gradually and include pain and stiffness, redness, warmth to the touch, and joint swelling. The joint stiffness is most bothersome in the morning and after sitting still for a period of time. The stiffness can persist for more than one hour.
- Hands – The joints of the hands are often the very first joints affected by rheumatoid arthritis. Between 1 and 5 % of people with rheumatoid arthritis develop carpal tunnel syndrome because swelling compresses a nerve that runs through the wrist which is characterized by weakness, tingling, and numbness of certain areas of the hand.
Certain characteristic hand deformities can occur with long-standing rheumatoid arthritis. swan neck deformities and boutonniere deformities, and may drift together in the direction of the small finger. The tendons on the back of the hand may become very prominent and tight, called the bow string sign.
- Wrist – The wrist is the most commonly affected joint of the arm in people with rheumatoid arthritis. In the early stages of RA, it might be not easy to bend the wrist backward.
- Elbow – Rheumatoid arthritis may cause inflammation of the elbow. Swelling of this joint may compress nerves that travel through the arm and cause numbness or tingling in the fingers.
- Shoulder – The shoulder may be inflamed in the later stages of rheumatoid arthritis, causing pain and limited motion.
- Foot – The joints of the feet are often affected in the early stages of rheumatoid arthritis symptoms, especially the joints at the base of the toes.
- Ankle – Rheumatoid arthritis may cause inflammation of the ankle. Inflammation of this joint may cause nerve damage, leading to numbness and tingling in the foot.
- Knee – Rheumatoid arthritis may cause swelling of the knee, difficulty bending the knee, excessive looseness of the ligaments that surround and support the knee, and damage of the ends of the bones that meet at the knee. RA may cause the formation of a Baker’s cyst (a cyst filled with joint fluid and located in the hollow space at the back of the knee).
- Hips – The hips may become inflamed in the later stages of rheumatoid arthritis symptoms. Pain in the hips may make it difficult to walk.
- Cervical spine – Rheumatoid arthritis symptoms may present as an inflammation of the cervical spine, which is the area between the shoulders and the base of the head.
- Cricoarytenoid joint -In about 30 % of people with rheumatoid arthritis symptoms, there is inflammation of a joint near the windpipe called the cricoarytenoid joint. Inflammation of this joint can cause hoarseness and difficulty breathing.
Other Rheumatoid Arthritis Symptoms – Although joint problems are the most commonly known issues in rheumatoid arthritis, the condition can be associated with a variety of other problems.
- Rheumatoid nodule – Rheumatoid nodule is painless lumps that appear beneath the skin. The nodule may move easily when touched or they may be fixed to deeper tissues.
- Felty’s Syndrome : Characterized by an abnormally enlarged spleen (splenomegaly).
- Amyloidosis : Infiltration of the liver, kidneys, spleen and other tissues with amyloid (starch like substance).
- Inflammatory conditions – Rheumatoid arthritis may produce a variety of other symptoms, depending on which tissues are inflamed.
- Pericarditis : Inflammation of the pericardium, tissue lining the chest cavity and surrounding the heart that may cause chest pain and difficulty breathing.
- Fibrosing Alveolitis : Inflammation of the lung that is not due to infection may cause shortness of breath and a dry cough.
- Peripheral sensory neuropathy, mononeuritis multiplex : Abnormal nerve function may cause numbness, tingling, or weakness.
- Sjögren’s syndrome : Dry eyes and dry mouth. women may develop vaginal dryness due to Sjögren’s syndrome, which can cause pain with sexual intercourse.
- Inflammation of the white part of the eye may cause pain or vision problems.
- Vasculitis – Inflammation of the blood vessels, may cause a wide variety of symptoms, depends on the location.
RHEUMATOID ARTHRITIS DIAGNOSIS – There is no single test used to diagnose rheumatoid arthritis. Instead, the diagnosis is based upon many factors, including the characteristic signs and symptoms, the results of laboratory tests, and the results of x-rays.
American Rheumatism Association: criteria for the diagnosis of rheumatoid arthritis
- Morning stiffness
- Pain on motion or tenderness in at least one joint
- Swelling of one joint, representing soft tissue or fluid
- Swelling of at least one other joint (soft tissue or fluid) with an interval free of symptoms no longer than three (3) months
- Symmetrical joint swelling (simultaneous involvement of the same joint, right and left)
- Subcutaneous nodules over bony prominences, extensor surfaces or near joints
- Typical X-ray changes that must include demineralisation in periarticular bone as an index of inflammation
- Positive test for rheumatoid factor in the serum
- Synovial fluid – a poor mucin clot formation on adding synovial fluid to dilute acetic acid
- Characteristic histopathology of rheumatoid nodules biopsied from any site
- Synovial histopathology consistent with RA:
(a) marked villous hypertrophy
(b) proliferation of synovial cells
(c) lymphocyte plus plasma cell infiltration in subsynovium
(d) fibrin deposition within or upon microvilli
• For classical RA 7 criteria needed
• For definite RA 5 criteria needed
• For probable RA 3 criteria needed