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What is The Treatment For Multiple Sclerosis – MS

July 13th, 2014 No comments

Cure Amidst No Cure: Dealing with Multiple Sclerosis

ms treatment options

Multiple sclerosis (MS) has no cure, so the doctors say. The only thing you can do about it is accept the fact that the worsening of MS can only be slowed down.

Doctors prescribe some types of medicines that could be used in the treatment for multiple sclerosis (MS) which are called “disease-modifying drugs.” These drugs help in suppressing flare-ups as well as changing how the immune system works to protect the nerves from damage. As a result, permanent disability can be prevented.

Most medicines administered for MS patients include Aubagio (teriflunomide), Avonex (interferon beta-1a), Copaxone (glatiramer acetate), Gilenya (fingolimod), and Novantrone (mitoxantrone).

 

Aubagio, Gilenya and Betaseron are used for the treatment of relapsing MS. While the first two are daily oral drugs, the latter is an injection drug for MS which is injected through the skin every other day. Avonex on the other hand is also used to treat relapsing MS but in addition helps in treatment subsequent to the occurrence of an infection. This medicine is injected to a muscle and is used once in a week. Lastly, Novantrone treats a relapsing-remitting MS, progressive-relapsing, and secondary-progressive MS types. The administration of this drug is through intravenous therapy just once in every three months.

 

You must be prepared for the side effects that you could experience along with the use of these medications. Common reactions are mild flu, nausea, liver problems and diarrhea, and hair loss. What you must ensure while you are on medication is to talk to your physician to have a guide on what is the effective one for you with the most tolerable aftereffect.

 

Treatment options for multiple sclerosis is not however limited to the administration of such medicines. There are also available alternatives that could help you live with MS: First, optimism. You have already been told that whatever you do, MS will be forever a part of your life now. You have been probably devastated since that moment but there is no turning back. All you need to do is to keep moving forward and manage whatever you can to help yourself, given your condition. You may cry today but maybe tomorrow should be different, right? Second, do some exercises.

 

You do not have to run to the gym and grab the nearest dumbbell you could find. Initially, you should ask your doctor about the right exercises to perform. You do not want to aggravate your condition by doing strenuous workouts. Yoga could be a good start for relaxation and peace of mind. Lastly, watch your diet. It is important to take note of healthy food such as manuka honey new zealand you should start eating to improve your physical condition.

 

Treating MS could also be best with some rest and interesting hobbies. You could start engaging in healthy relationships too to get along with your disease just fine. Find out more about Treatment Options for MS click here.

Michelle Obama, Buddhist Monk, Tai Chi, And VIEW GALLERY

March 28th, 2014 No comments

After the search for Flight 370 debris moved 680 miles to the northeast, five planes took images of “objects.” Those will be analyzed in Australia. FULL STORY

In Bangkok, a Buddhist monk takes a punch. In China, Michelle Obama learns tai chi. In Houston, a construction site goes up in flames….

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Signs and Symptoms of Multiple Sclerosis-How is MS Diagnosed

January 28th, 2014 No comments

Multiple sclerosis (MS) is the most common cause of progressive neurological disability in the 20-50 year age group. The Signs and Symptoms of Multiple Sclerosis is vast, early diagnosis is difficult because MS is characterised by widespread neurologic lesions that cannot be explained by a single anatomical lesion, and the various signs and symptoms are subject to irregular exacerbations and remissions. The most important issue in diagnosis is the need for a high index of suspicion.

Signs and symptoms of multiple Sclerosis MS
What Causes MS? MS is a primary demyelinating disorder with demyelination occurring in plaques throughout the white matter of the brain, brainstem, spinal cord and optic nerves. The clinical features depend on their
location.

Clinical features – Signs and Symptoms of Multiple Sclerosis

> more common in females
> peak age of onset is in the fourth decade
> symptoms develop over several days but can be sudden
> transient motor and sensory disturbances
> upper motor neurone signs
> monosymptomatic initially in about 80%
> multiple symptoms initially in about 20%
> common initial symptoms include:
> visual disturbances of optic neuritis
– blurred vision or loss of vision in one eye (sometimes both)
– central scotoma with pain on eye movement (looks like unilateral papilloedema)
> diplopia (brainstem lesion)
> weakness in one or both legs, paraparesis or hemiparesis
> sensory impairment in the lower limbs and trunk
– band-like sensations
– numbness, paraesthesia
– clumsiness of limb (loss of position sense)
– feeling as though walking on cotton wool
> vertigo (brainstem lesion)
> subsequent remissions and exacerbations that vary from one individual to another
> there is a progressive form especially in women around 50 years

Neurological examination
The findings depend on the site of the lesion or lesions and include optic atrophy, weakness, hyperreflexia,
extensor plantar responses, nystagmus (two types: cerebellar or ataxic), ataxia, incoordination and regional impairment of sensation.

Signs and Symptoms of MS causing diagnostic confusion
> bladder disturbances, including retention of urine and urgency
> ‘useless hand’ due to loss of position sense
> facial palsy
> trigeminal neuralgia
> psychiatric symptoms

In established disease common sign and symptoms of ms are fatigue, impotence and bladder disturbances.

How is MS Diagnosed?

The diagnosis of MS is clinical and depends on the following determinants:

  • Lesions affect the CNS white matter.
  • Lesions are invariably UMN.
  • >1 part of CNS is involved, although not necessarily at time of presentation.
  • Episodes are separated in time (it is possible to make a diagnosis with the first episode).

Other neurological diseases such as infections (e.g. encephalitis), malignancies, spinal cord compression, spinocerebellar degeneration and others must be excluded.

For Diagnosing MS, some Lab and Imaging are needed

  • Lumbar puncture: oligoclonal IgG detected in CSF in 90% of cases 8 (only if necessary)
  • Visual evoked potentials: abnormal in about 90% of cases
  • CT scan: rarely demonstrates MS lesions but useful in excluding other pathology
  • MRI scan: usually abnormal, demonstrating MS lesions in about 90% of cases 8

 

 

Sarcoidosis Treatment Natural Remedies

November 27th, 2012 No comments

natural remedies for sarcoidosis

Sarcoidosis
Sarcoidosis is a multisystemic disorder of unknown aetiology which is characterised by non-caseating
granulomatous inflammation that involves the lung in about 90% of affected patients. A characteristic
feature is bilateral hilar lymphadenopathy, which is often symptomless and detected on routine CXR.
Radiological lung involvement can be associated with or occur independently of hilar lymphadenopathy.
Clinical features:

  • may be asymptomatic (one-third)
  • onset usually 3rd or 4th decade (but any age)
  • bilateral hilar lymphadenopathy (on CXR)
  • cough
  • fever, malaise, arthralgia
  • erythema nodosum
  • ocular lesions, e.g. anterior uveitis
  • other multiple organ lesions (uncommon)
  • overall mortality 2-5%

Erythema nodosum with acute fever, malaise and arthralgia in a young adult female is diagnostic of
sarcoidosis.

Diagnosis
Histological evidence from biopsy specimen, usually transbronchial biopsy (essential if an alternative
diagnosis, e.g. lymphoma, cannot be excluded) or skin biopsy in cases of erythema nodosum.

Supporting evidence:

  • elevated serum ACE (non-specific)
  • PFTs: restrictive pattern; impaired gas transfusion in advanced cases.
  • ±ve Kveim test (not recommended these days)

Treatment
Sarcoidosis may resolve spontaneously (hilar lymphadenopathy without lung involvement does not require treatment). About half of all people with sarcoidosis get better without needing treatment. For others, medications such as corticosteroids may help reduce swelling, rashes, pain, fever, and lung problems. Some lifestyle changes may help control complications, such as kidney stones or other damage. While complementary therapies for sarcoidosis have not been well studied, they may help you feel better as part of an overall treatment plan.
Indications for treatment with corticosteroids:

  • no spontaneous improvement after 6 months
  • symptomatic pulmonary lesions
  • eye, CNS and other systems involvement
  • hypercalcaemia, hypercalcuria
  • erythema nodosum with arthralgia
  • persistent cough

Lifestyle

If you smoke, quit. Quitting smoking can ease lung symptoms.

Sarcoidosis can be a long-lasting disease, so it’s important to eat a healthy diet filled with fruits, vegetables, and whole grains.

Exercise regularly. Be sure to ask your doctor before starting a new exercise program, especially if sarcoidosis leaves you short of breath.

Medications

Corticosteroid treatment
Prednisolone 30 mg daily for 4-6 weeks, then reduce to lowest dose that maintains
improvement. 6 If there is no response, taper the dose to zero. If there is a response, taper the
dose to 10-15 mg (o) daily as a maintenance dose for 6-12 months. 14
Prednisolone 20-30 mg for 2 weeks for erythema nodosum of sarcoidosis.

Corticosteroids such as prednisone are considered the first-line treatment for lowering inflammation associated with sarcoidosis. Oral corticosteroids can have some serious side effects if taken in high doses for long periods. Side effects may include high blood pressure, diabetes, peptic ulcers, tuberculosis, or osteoporosis. Your doctor will likely suggest regular check-ups and tests.

Other medications sometimes used for sarcoidosis include those that suppress the immune system, such as methotrexate, azathioprine (Imuran), and infliximab (Remicade). However, there are no long-term studies on whether these medication are effective for treating sarcoidosis.

Other medications that may be used include:

Antimalarial drugs such as hydroxychloroquine — used when the skin is affected. It may be toxic to the eyes.

Thalidomide — being studied for sarcoidosis; used to improve lung function and treat skin problems.

Surgery and Other Procedures

Surgery, such as a lung or heart transplant, is only necessary in very severe cases.

Nutrition and Dietary Supplements

Although there is no evidence that any particular herb or supplement helps treat sarcoidosis, a comprehensive treatment plan may include complementary and alternative therapies. Ask your team of doctors about the best ways to bring these therapies into your overall treatment plan. Always tell your doctor about the herbs and supplements you are using or considering using, as some supplements may interfere with conventional treatments.

These nutritional tips will help your overall health:

  • Eat antioxidant foods, including fruits (such as blueberries, cherries, and tomatoes), and vegetables (such as squash and bell peppers).
  • Include foods rich in magnesium and low in calcium, such as barley, bran, corn, rye, oats, soy, brown rice, avocado, banana, and potato.
  • Avoid refined foods, such as white breads, pastas, and sugar.
  • Eat fewer red meats and more lean meats, cold-water fish, tofu (soy, if no allergy) or beans for protein.
  • Use healthy oils, such as olive oil or vegetable oil.
  • Reduce or eliminate trans-fatty acids, found in commercially baked goods such as cookies, crackers, cakes, French fries, onion rings, donuts, processed foods, and margarine.
  • Avoid caffeine, alcohol, and tobacco.
  • Drink 6 – 8 glasses of filtered water daily.
  • Exercise at least 30 minutes daily, five days a week. Ask your doctor before starting a new exercise routine.

The following supplements may also help overall health:

  • A daily multivitamin, containing the antioxidant vitamins A, C, E, the B-complex vitamins, and trace minerals such as magnesium, calcium, zinc, and selenium.
  • Omega-3 fatty acids, such as fish oil, 1 – 2 capsules or 1 – 3 tablespoonfuls oil, one to three times daily. Fish oil seems to help reduce inflammation throughout the body. Cold-water fish, such as salmon or halibut, are good sources to add to your diet. If you take supplements, check with your doctor because they may increase the risk of bleeding, especially if you take blood thinners such as warfarin (Coumadin) or aspirin. Eating fish doesn’ t cause the same risk.
  • Bromelain, a mixture of enzymes derived from pineapple, 500 mg per day. Bromelain may also help reduce inflammation in the body. Ask your doctor before taking it, because it can increase the risk of bleeding and may interact with other medications.
  • Probiotic supplement (containing Lactobacillus acidophilus), 5 – 10 billion CFUs (colony forming units) a day. These “friendly” bacteria help maintain gastrointestinal health. You should refrigerate your probiotic supplements for best results.

Herbs : Natural Remedies

Herbs are generally a safe way to strengthen and tone the body’s systems. As with any therapy, you should work with your health care provider to get your problem diagnosed before starting any treatment. You may use herbs as dried extracts (capsules, powders, teas), glycerites (glycerine extracts), or tinctures (alcohol extracts). Unless otherwise indicated, you should make teas with 1 tsp. herb per cup of hot water. Steep covered 5 – 10 minutes for leaf or flowers, and 10 – 20 minutes for roots. Drink 2 – 4 cups per day. You may use tinctures alone or in combination as noted.

Studies haven’ t found any herbs that specifically treat sarcoidosis. However, the following herbs may help overall health. Talk to your doctor before taking any herb or supplement if you have sarcoidosis.

  • Turmeric (Curcuma longa) standardized extract, 300 mg three times a day, may help reduce inflammation. Turmeric may increase the risk of bleeding and interact with other medications, so ask your doctor before taking it.
  • Cat’s claw (Uncaria tomentosa) standardized extract, 20 mg three times a day, may help reduce inflammation. People with leukemia should not take cat’ s claw. Cat’ s claw interacts with some medications, so ask your doctor before taking it.

Homeopathy

A few case reports suggest that homeopathic remedies may improve the general well-being of individuals with sarcoidosis. An experienced homeopath can prescribe a regimen for treating sarcoidosis that is designed specifically for each individual. The primary remedies used by individuals who reported improvements in their symptoms include:

  • Tuberculinum bovinum
  • Beryllium

Other homeopathic remedies that have been used clinically for the condition are as follows:

  • Carcinosin
  • Euphrasia
  • Graphites
  • Leuticum (Syphilinum)
  • Bacillinum
  • Sepia
  • Phosphorus
  • Arsenicum album

Polymyositis and Dermatomyositis Symptoms

July 3rd, 2012 No comments

Polymyositis and Dermatomyositis

Polymyositis is an unheard of wide spread disorder whose main feature is balanced muscular tissue weakness
and throwing away involving the proximal muscles of the shoulder and pelvic girdles.
Polymyositis + associated breakout = dermatomyositis

dermatomyositis heliotrope rash

Clinical components

  • any age
  • peak occurrence 40-60 years
  • female to male proportion 2:1
  • muscular tissue disadvantage and losing proximal limb muscular tissues
  • major problem is weakness
  • muscular tissue discomfort and inflammation in concerning FIFTY %
  • arthralgia or arthritis in regarding FIFTY % (resembles circulation of rheumatoid arthritis)
  • dysphagia in concerning 50 % as a result of oesophageal involvement
  • Raynaud’s phenomenon
  • think about linked malignancy: lung and ovary

The breakout

The unique rash shows attributes of photosensitivity. There is violet staining of the eyelids,.
forehead and cheeks, and possible erythema appearing like sunburn and periorbital oedema. There is a.
particular rash on the hands particularly the fingers and nail folds. The knees and elbows are.
generally included.

.

Polymiositis and dermatomyositis symptoms

 

Diagnosis
muscle enzyme studies (serum creatine kinase and aldolase)
biopsies—skin and muscle
EMG studies—show characteristic pattern

Teatment

includes corticosteroids and cytotoxic drugs. Early referral is appropriate.

Autoimmune Illness Symptoms – What is The Real Source?

April 23rd, 2012 No comments

You can only submit entirely new text for analysis once every 10 seconds.n out of the bloodstream (to help its survival) and sequestering it into the fatty tissue. This is considered a safer storage than in the bloodstream itself.

Our bodies then release chemicals to convert these fat-soluble poisons into a water-soluble form so that they can be eliminated through the stool and the kidney. However, the higher the toxic load, the more compromised the detoxification pathways and the more overtaxed the organs of elimination. Consequently, this bio-accumulation of contaminants stays stored in the organs and tissue. While there, they compete for the same biological space as many nutrients. Therefore, one becomes both poisoned AND undernourished.

To add insult to injury, these contaminants create a hospitable terrain where opportunistic organisms can thrive. This can lead to a yeast and fungal overgrowth in the small intestine, as well as to the increase of bad bacteria, parasites, and a condition called leaky gut, where more toxins from the gut “leak’ into the bloodstream.

All of this triggers what the Japanese call “diseases of the toxic burden”.

What Is The Autoimmune Reaction To All Of This?

When bio-accumulation in the gut and in the tissue becomes extremely elevated, or when a toxin is introduced into the bloodstream in a condition of “leaky gut”, this triggers a reaction where auto-antibodies are released. The initial intention of these auto-antibodies is to find these toxins, these pathogens, and to inflame them so that the white blood cells can use the inflammation as markers to destroy these invaders. However, because this toxic insult is so prevalent, and because this auto-antibody release is 24/7, surrounding healthy tissue also gets inflamed, a sort of collateral damage. After a while, cellular communication breaks down completely and the auto-antibodies cannot distinguish between a pathogen and one’s own healthy tissue. This is when the full force of the body’s immune function turns on itself – a case of misplaced immunity or autoimmunity.

The more the planet carries this burden, the more human bodies carry this burden – and the more the body adapts in creative and confused ways. Many of the autoimmune disorders that are so prevalent now were not around even 25 or thirty years ago. Thirty-five years ago, did you know anybody with fibromyalgia or environmental sensitivity or Type II diabetes or chronic fatigue? How about Autism or symptoms along that spectrum like attention deficit? How about “dry eye syndrome” or the numerous folks you meet who have a sluggish thyroid or a candida infestation? How about the increasing numbers of people who have gluten, casein, corn or soy sensitivities? How many people did you know 30 years ago who could not eat dairy? Or be in the same room as someone with perfume?

All these are autoimmune in nature. And all these are triggered by the increasing toxic insult by our preserved, make-believe foods and by our environment.

Modern man equals great creative innovations. And modern man also equals a slow destruction of the human organism.

The Final Say

We all believe that we “get” these disorders when, in actuality, we “do” these disorders, unintentional though it may be. Our health, or lack of it, is the by-product of our lifestyle choices: the foods that we eat, the air that we breathe, the water that we drink, the attitudes and the stress that we hold. It is said that “Genetics loads the gun, but environment pulls the trigger” and it is no more true than it is today. We cannot control our genetics, but we can make conscious, informed and loving choices about our environment – both inner and outer terrains.

Very simply, the key lies in taking the poison out of our tissue and brains AND in getting proper, whole food nutrition and supplements to our cells. Address our toxic load and the subsequent undernourishment. This we can control!

The answers do not lie in a laboratory where someone is going to discover “the magic bullet” that saves us all. No one else can give us what we refuse to give ourselves. And no one can deny us what we freely give to ourselves.

There is no magic bullet. Never has been. Technology and the control by the vested interests is not the key. Empowering yourself with honest information and then having the courage and the discipline to implement it into your life IS the key.

Genetics DOES load the gun, but the trigger does not HAVE to be pulled. It is up to each of us, first as individuals, and then as the collective. We can grow more conscious and more healthy together.

Cutaneous Sarcoidosis – All You Need to Know and Exciting New Information

February 8th, 2012 No comments

Cutaneous Sarcoidosis – All You Need to Know and Exciting New Details

Cutaneous Sarcoidosis

Cutaneous sarcoidosis as other individual forms of sarcoidosis isn’t really simple to recognize the means it can mirror bunches of various other ailments. Due to this, skin sarcoidosis is also called the ‘wonderful imitator’ in dermatology.

Cutaneous sarcoidosis happens in as much as one 3rd regarding people with systemic sarcoidosis. It is extremely important recognize skin sarcoidosis thinking about that it could supply crucial insight in the improvement of the problem with the skin sores being so available for histologic checking.

Cutaneous sarcoidosis Medical diagnosis

You do not have single test which could certainly identify the particular visibility of sarcoidosis. Consequently the intention is generally to finish a clinical picture to see histological proof with noncaseating granulomas.

Additionally, the wellness professional might be looking to dismiss various other possible trigger of the exact same symptoms, for example infections.

Cutaneous sarcoidosis – particular and nonspecific indications on the ailment

All indications of skin sarcoidosis are typically split into number of teams, certain along with non-specific:.

.

  • Non-specific (no granuloma is situated in the tissue biopsy)

.

  • Specific (granuloma is situated in the cells biopsy)

Erythema Nodosum

Erythema Nodosum is the best nonspecific cutaneous lesion about sarcoidosis. It occurs in the form of soreness of your skin created by congestion from the blood vessels, which might result from a selection of reasons. In cutaneous sarcoidosis, this typically indicates that that spots appear associating with the legs – the shins much more reguarily then other individual parts.

Papules

The most familiar sorts of accurate lesions are papules. They commonly develop associating with the face however could possibly develop anywhere to the physical body and can be different in color consisting of red, reddish-brown as well as violaceous.

Plaques

Cavity enducing plaques are really bigger, sores that perform the face and they typically have a fat-free top torso, or perhaps extremities. The sores might maybe be solitary or numerous and will also be different in tone.

Lupus pernio

Lupus pernio is amongst the few cutaneous symptoms which could be particular of sarcoidosis. A lot more consistently after that not, it has an effect on the edge belonging to the nose. It can be acknowledged by all the characteristic purplish color selection.

Cutaneous sarcoidosis – Treatment

Very much like various other kinds connected with sarcoidosis, dental steroids are typically utilized in cutaneous sarcoidosis. Procedure which may be certain just for cutaneous sarcoidosis are typically topical corticosteroids emulsions.

Lupus Symptoms in Pregnant Women

September 9th, 2011 No comments

Lupus Symptoms in Women – Pregnancy

lupus symptoms in women

lupus symptoms in women

Lupus Symptoms in women is surely an autoimmune disease which commonly affects women, although men can also have the lupus symptoms,  and often many experts have said that women who have lupus symptoms cannot become pregnant due to their condition. However, this myth has been denied by specialists, approximately 50% of  pregnant women who has lupus symptoms can have a ordinary pregnancy and give birth healthy babies. Conversely, some women might possibly face complications and even lose their fetuses during the pregnancy.

Whilst many pregnancies with lupus are totally natural, women risk to facing problems over their pregnancy. The expectant mother with lupus need to be supervised by an expert doctor (obstetrician) till the end of pregnancy,  in other words, the health risk of the mother’s is definitely diminished and normal babies are usually born. In addition, women with lupus symptoms must obey the doctor’s instruction manuals.

Pregnant women with symptoms of lupus may perhaps face particular symptoms which includes rashes and lupus flare which can appear because of an increased blood flow in the skin, growth of new hair during pregnancy plus severe hair loss after the baby born.

One of the important things we need to notice is that 20% of lupus patients who are pregnant tend to have an abrupt rise in BP (blood pressure), protein in the urine, a condition which you’ll find known as Preeclampsia or toxaemia and degree of serious treatment as well as immediate delivery. The presence of antibody called anti-phospholipid antibody could occur to lupus pregnancies which is another serious complications.  Anti-phospholipid antibody can minimize the function of the placenta by bring about blood clots, as well as blood clots within the placenta, making the placenta to higher risks. Neonatal Lupus Syndrome can occur in lupus pregnancy when the unborn children are exposed to an antibody known as anti-ro or anti-SSA. In many events, women who has severe form of lupus symptoms in pregnancy  have to get through a caesarian section to conserve the premature baby.

Even though, lupus patient in remission generally have less problem when compared with women with activate lupus, a balanced healthy diet could actually help a lot throughout the pregnancy. There are some golden rules to be followed by pregnant woman living with lupus, they are: regularly visits on the doctor, proper prescription of  medication, stay away from pills that can put the baby’s life in danger, a sensible food diet, as well as no bad habits like smoking or drinking.

In conclusion, a normal pregnancy can be carried on by pregnant women who put up with lupus symptoms if  they follow the suitable management and have an equalize standard of living. Moreover, it has been taken into account that most medications for Systemic Lupus Erythematosus (SLE) are safe to be used during the pregnancy given that that they don’t pass through the placenta.

Systemic Lupus Erythematosus Can Create Death

September 6th, 2011 No comments

Nobody passes away from lupus ~ many die from the difficulties.

Systemic Lupus Erythematosus Can Cause Death

Lupus is problematic to detect in addition to more challenging to manage. There is no solitary examination that diagnoses Systemic Lupus Erythematosus (SLE) which is incurable, chronic problem.

Wide spread Lupus Erythematosus happens to be a not curable autoimmune ailments, which holds the potential to disable and take lives therefore invading: healthy and balanced skin cells, tissues, central nerves (CNS), numerous physical systems, blood, and important body organs – brain, heart, lungs, renals and so on

. SLE is not transmittable nor cancerous, and in fact it is quite common. It is pertained to far more frequent than AIDS, Spastic paralysis, Sickle Cell Anemia, Cystic Fibrosis and Multiple Sclerosis (MS) ~ collaborated.

Everybody, men or females, young people, and the aging adults can create lupus – despite the fact that, even more ladies are normally more likely compared to guys for being diagnosed with Systemic Lupus Erythematosus. There are much more Eastern lupus people, rather ased opposed to Caucasians, who require, and are most likely to get, the illness.

There are 4 acknowledged types of lupus, baseding on the American Lupus Foundation:.

    • Cutaneous Lupus Erythematosus
    • Drug-induced Lupus Erythematosus
    • Neonatal Lupus
    • Systemic Lupus Erythematosus

Systemic lupus is the most regular type of lupus, in addition to being exactly what a lot of people mean if they refer to “lupus.” Wide spread Lupus Erythematosus is normally moderate or considerable.

Where Does Systemic Lupus Erythematosus strike?

Systemic lupus erythematosus, which is not treated, could be dangerous. The symptoms are so considerable as the condition itself. Among several saddest facts of the disease is that it’s generally not diagnosed prior to the patient comes to be, in the short-term or entirely, crippled or exists to a dangerous stage on the ailment.

The Symptoms are various from a person to the various other person, consisting of: distressing debilitating joint, and chronic fatigue, seizures and important/vital organ (lungs, kidneys, mind and heart) does not partner correctly, memory issues (aka lupus fog) in addition to confusion, arteriosclerosis, aching throats, hair thinning and even fevers, a breakout over the bridge of the nose and cheeks (butterfly breakout).

Problems could not be shown by an un-diagnosed person, while the illness is working surreptitiously attacking the blood circulation by creating blood clots. These embolism could take place in anywhere within the body, featuring the mind and lungs. This might cause a stroke, possibly fatality. Just like any sort of life-altering or perhaps deadly conditions, the morbidity Systemic Lupus Erythematosus applies can be devastating if left without treatment.

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August 26th, 2011 No comments

pharmacological treatment of lupus

Pharmacological Treatment of SLE

As we have actually published on the Lupus Procedure Tips, which is mainly go over regarding Non Pharmacological Lupus Procedure. In this part The Pharmacological Procedure of Lupus will be described. Below are the Pharmacological representatives:.

Immunomodulatory therapy

1. Cyclophosphamide.

Is the primary medicine in extreme organ system conditions, especially lupus nephropathy. Therapy with Corticosteroid and cyclophosphamide (iv bolus 0.5 to 1 gram/m2) is much more effective compared to just a corticosteroid alone, in the prevention of renal system sequele, keep renal function and renal generate remission. Effective non-renal indications with cyclophosphamide is sitopenia, main nerves abnormalities, lung hemorrhage and vasculitis.

Oral administration at a dose of 1 to 1.5 mg / kilograms might be raised to 2.5 to 3 milligrams / kilograms with the disorder of neutrophils> )1000/mm3 and leukocytes> )3500/mm3. Tracking the number of leukocytes were reviewed every 2 weeks and intravenous therapy with an amount of 0.5 to 1 gram/m2 every 1-3 months.

Negative side effects that frequently happen are nausea or vomiting, vomiting, hair loss can sometimes be discovered but it disappeared when the drug is stopped.Dose-dependent leukopenia often develops after 12 days of procedure to ensure that dose change is needed with leukocytes. The danger of microbial infections, fungi and pc virus, especially herpes zoster increases. Negative effects on the gonads that is triggering the failing of ovarian feature and azospermia. Stipulation of gonadotropin hormone launching bodily hormone or oral contraceptive pills has actually not been shown reliable. In SLE people with lupus nephropathy that become pregnant this course of medicines need to be stayed away from.

2. Mycophenolate mofetil (MMF).

MMF is a relatively easy to fix prevention of inosine monophosphate dehydrogenase, an enzyme important for purine synthesis. MMF would certainly stop the expansion of B and T cells and decreased expression of adhesion molecules. MMF successfully decrease proteinuria and improve serum creatinine in people with SLE and nephritis resistant to cyclophosphamide. Negative side effects that take place are typically leukopenia, queasiness and diarrhea. The combo of MMF and Prednisone as effective as dental management cyclophosphamide and prednisone adhered to by azathioprine and prednisone. MMF is provided at a dosage of 500-1000 mg two times daily until the response to drug treatment and amount adapted to feedback. In SLE clients with lupus nephropathy that become pregnant this course of medicines must be avoided.

3. Azathioprine.

Azathioprine is a purine analog that inhibits nucleic acid synthesis and influences the cellular and humoral invulnerable function. In SLE this drug is used as an option to cyclophosphamide for the therapy of lupus nephritis or as a steroid sparing agent for non-renal manifestations such as myositis and refractory synovitis. Giving beginnings with a dosage of 1.5 milligrams / kg / day, if needed could be boosted with the moment interval 8-12 weeks to be 2.5 to 3 mg / kg / day supplied that the leukocyte matter>) 3500/mm3 and metrofil>) 1000. If given up combination with the allopurinol dosage ought to be decreased to 60-75 %. Negative effects that happened a lot more highly effective than cyclophosphamide, which usually happens is bone bottom reductions and food poisonings. Azathioprine is also usually related to hypersensitivity to the sign of fever, skin rashes and increased serum transaminases. Complaints are generally relatively easy to fix and vanish after the drug is stopped. Consequently metabolized in the liver and secreted in the k.idneys liver and kidney function should be checked periodically. This drug is an immunomodulatory options in patients with lupus nephropathy who become pregnant, given at a dose of 1 to 1.5 mg / kg / day because it is relatively safe.

4.Leflunomide (Arava)

Leflunomide is an inhibitor of de novo synthesis of pyrimidin approved in the treatment of rheumatoid arthritis. Several studies have reported benefits in patients with SLE which was originally given because of steroid dependence. Giving starts with a loading dose of 100 mg / day for 3 days followed by 20 mg / day.

5.Methotrexate

Methotrexate is administered at a dose of 15-20 mg orally once a week, and proved particularly effective for skin and joint complaints. Side effects that usually happens is an increase in serum transaminases, gastrointestinal disorders, infections and oral ulcers, so it needs to be monitored closely liver and kidney function. In SLE patients with lupus nephropathy who become pregnant this class of drugs should be avoided.

6.Cyclosporine

Giving a dose cyclosporine 2.5 to 5 mg / kg / day was generally well tolerated and lead to real improvements to the proteinuria, sitopenia, immunological parameters (C3, C4, anti-ds DNA) and disease activity. If creatinine increased by more than 30% or hypertension arises then the dose should be adjusted to a common side effect is hypertension, gum hyperplasia, hipertrikhosis, and increased serum creatinine. Cyclosporine is especially beneficial to membranous nephritis and nephrotic syndrome refractory to, so monitoring blood pressure and kidney function should be performed routinely. Cyclosporine A may be given to people with lupus nephropathy who become pregnant, given at a dose of 2 mg / kg / day because it is relatively safe.

Biological Agents

1.Activation of T cells, the interaction of T cells and B cells, B cell depletion

Recent developments have focused therapy of B cell function in taking autoAg and present it through the immunoglobulin-specific T cells in the cell surface, further influence T cell-dependent immune response Anti CD 20 is a monoclonal antibody against the receptor CD 20 B lymphocytes presented

2.Anti CD 20

Anti-CD 20 (Rituximab; Rituxan) has the potential of the therapy for refractory SLE. Several studies provide therapeutic efficacy in refractory lupus manifestations such as central nervous system, vasculitis and hematological disorders.

3.LJP 394

LJP 394 (Abetimus sodium; Riquent) has been designed to prevent recurrence of renal flare in nephritis patients by reducing antibody against ds-DNA through a selective antigen-specific tolerance. The substance is a synthetic compound that consists of a series of deoxyribonucleotides which bound to the triethylene glycol chains.

4.Anti-B lymphocyte stimulator

B lymphocyte stimulator (BlyS) is part of the cytokine TNF (tumor necrosis factor), which presented the B cellsLymphoStatB a monoclonal antibod against BlyS.

5.Cytokine inhibitors

Although there have been studies showing decreased secretion of TNF alpha and melioration leukopenia, proteinuria and immune complex deposition in experimental animals, but no clinical studies that administered anti-TNF agents in patients with SLE.

6.Anti-malarial

Antimalarial drugs used in SLE is hydroxychloroquine, chloroquine, and quinakrin. Used to constitutional complaints, manifestations in the skin, musculoskeletal and serositis. Antimalarial drug combinations have a synergistic effect and is used when the use of one drug is not effective. Hidroksiklotokuin (200-400 mg / day) and Quinakrin (100 mg / day) as a steroid sparing agents have side effects are mild and reversible, ie the skin becomes yellowish discoloration.

The mechanism of how hydroxychloroquine to prevent organ damage is unclear. Hydroxychloroquine lowering lipid levels and possible anti-thrombotic. Noteworthy are the side effects on the eye although it is relatively safe when used at low dois (<6.5 mg / kg / day). However, the current recommendation is to perform eye examinations before starting treatment and every 6-12 months later. Antimalarial rarely cause congenital abnormalities in the fetus. Therefore direkomendasaikan to be given also in patients with lupus nephropathy of pregnancy and lactation can be given up. Incidence of IUGR was also reduced by administering hydroxychloroquine.

Sex Hormones

Bromocriptine which selectively inhibits the anterior pituitary to secrete prolactin prove useful to reduce SLE disease activity. Dehydroepiandrosterone (DHEA) is useful for SLE with mild to moderate activity. Danazole (synthetic steroids) with doses of 400-1200 mg / day to control cytopenia especially thrombocytopenia and autoimmune hemolytic anemia. Estrogen replacement therapy (ERT) may be considered in patients with SLE who experience menopause, but there is still debate about the ability of oral contraceptives or ERT in the cause of SLE flares. For that this therapy should be postponed in patients with a history of thrombosis.
Corticosteroids

Corticosteroids are effective in treating a variety of clinical manifestations of SLE. Topical or intralesional dosage used for skin lesions, intra-articular preparations used for arthritis, while preparations for oral or parenteral systemic abnormalities. Giving oral dose varied from 50-30 mg of prednisone (methylprednisolone) per day in single or divided doses, is effective for treating the constitutional complaints, skin disorders, arthritis and serositis. Often given concurrently with corticosteroids or immunomodulatory antimalarials in order to get a quick induction then lowered the dose.The involvement of vital organs such as nephritis, cerebritis, hematological abnormalities or systemic vasculitis, generally require high doses of prednisone (1-2 mg / kg / day). Parenteral Corticosteroids can also be used in cases of very severe, life-threatening, with a bolus dose of 1000 mg methylprednisolone for 3 consecutive days.

Undesirable effects of glucocorticoids on long including cushingoid habitus, weight gain, hypertension, infection, capillary fragility, acne, hirsutism, accelerated osteoporosis, ischemic bone necrosis, cataract, glaucoma, diabetes mellitus, myopati, hypokalemia, irregular periods, irritability, insomnia, and psychosis. Therefore after a controlled disease activity, corticosteroid dose should be lowered or discontinued if possible or given in daily doses of the smallest interval.

To minimize osteoporosis, calcium supplements can be given 1000 mg / day in patients with 24-hour urinary calcium excretion over 120 mg. Given 50,000 units of vitamin D is also 1-3 times a week (monitor hypercalcaemia). In preventing osteoporosis can also be given calcitonin and bisphosphonates (alendronate, Didronel or Actonel). Corticosteroids are generally well tolerated during pregnancy although it can cause exacerbation of diabetes and hypertension. There is no evidence that corticosteroids cause congenital defect but may cause low birth weight babies and premature rupture of membranes.

NSAIDs (Non Steroid Anti Inflammatory Drug)

NSAIDs are used to deal with complaints of musculoskeletal pain, pleurisy, pericarditis, and headache. Side effects of NSAIDs on the kidneys, liver, central nervous system should be distinguished from the intense activity of lupus. The presence of proteinuria is an emerging or worsening renal function may be caused by SLE activity or effects of NSAIDs. NSAIDs can also cause aseptic meningitis, headache, psychosis and cognitive impairment, increased serum transaminase reversibly. Gastrointestinal disorders are the most frequent side effects caused by non-selective COX inhibitor. COX-2 selective inhibitors fewer gastrointestinal side effects. In SLE patients with lupus nephropathy who become pregnant this class of drugs should be avoided because it can lead to congenital abnormalities and is excreted in breast milk.

Plasmapheresis

The role of plasmapheresis in lupus nephropathy remains controversial. The indication is a case of lupus with cryoglobulinaemia, hyperviscosity syndrome and TTP (Thrombotyc Thrombocytopenic Purpura).

Intravenous immunoglobulin

Intravenous immunoglobulin (IV Ig) are immunomodulators with a wide working mechanism, including Fc receptor blockade, complement regulation and T cellUnlike immunosuppressant, IV Ig has no effect to increase the risk of infection. Dose of 400 mg / kg / day for 5 consecutive days provide improvements to the thrombocytopenia, arthritis, nephritis, fever, skin manifestations and parameters of immunologically. Side effects that occur are fever, myalgia, headache and arthralgia, and occasionally aseptic meningitis. Contraindications given to patients with SLE with IgA deficiency.

Summary :

To be able to diagnose lupus required a good understanding of Lupus pathophysiology. In addition to symptoms and signs listed in the ACR criteria we need to know that many variations of other manifestations, especially in the skin and the central and peripheral nervous system. More often handling must be carried out in patients who do not fully meet the ACR criteria but suffered life-threatening condition, such as CNS lupus, hemolytic crisis, severe nephritis and poliserositis that does not prove there are other causes. On the other hand we too are required not to overdiagnostic for cases not yet clear. Handling of lupus often require cooperation intra-and inter-disciplinary branch of medicine. It is wise if the doctors who deal with lupus we include peer group or support group in providing education to patients with lupus. Lupus Treatment requires comprehensive understanding as well as astute skills.

A comprehensive treatment plan for lupus may include a range of complementary and alternative therapies (Natural remedies for lupus).

Nutrition and Supplements

Eating a healthy diet with plenty of fruits, vegetables, and whole grains is important for anyone with a chronic disease. People with lupus may also benefit from the following strategies:

Eat more antioxidant-rich foods (such as green, leafy vegetables) and fruits (such as blueberries, pomegranates, and cherries).
Avoid refined foods, such as white breads, pastas, and sugar.
Eat fewer red meats and more lean meats, cold-water fish, or beans for protein.
Use healthy cooking oils, such as olive oil or vegetable oil.
Avoid coffee and other stimulants, alcohol, and tobacco.
Drink plenty of fluids.
Exercise moderately at least 30 minutes daily, 5 days a week.

The following supplements may also help:

Flaxseed (30 g per day) contains omega-3 fatty acids and alpha-linolenic acid, which may help decrease inflammation. One preliminary study suggested that people with lupus who took flaxseed had better kidney function — important because kidney disease (lupus nephritis) is a major complication of lupus.
Fish oil, which also contains omega-3 fatty acids, may help decrease inflammation. Although evidence is mixed about taking a fish oil supplement, doctors do suggest that people with lupus eat more fish. Cold-water fish, such as salmon or halibut, are good sources. Talk to your doctor before taking a fish oil supplement if you also take anticoagulants (blood-thinners), such as warfarin (Coumadin). Eating fish doesn’ t cause the same risk.
Dehydroepiandrosterone (DHEA), start at 5 mg three times a day and work up to 100 – 200 mg per day for 7 – 12 months. Do not take DHEA without your doctor’ s supervision. DHEA is a precursor to the hormones estrogen and testosterone in the body, and several clinical trials show that it may help improve symptoms of lupus. However, side effects — including acne, increased facial hair, and excessive sweating — were common. DHEA may also lower HDL (good) cholesterol, which could contribute to heart disease. Because of DHEA’ s hormone-like effects, people with a history or higher risk of breast, uterine, ovarian, or prostate cancer should not take DHEA.
Calcium and vitamin D supplement, 1 – 2 tablets daily if taking corticosteroids. Corticosteroids can raise the risk of osteoporosis, and calcium and vitamin D can help keep bones strong.
Methylsulfonylmethane (MSM), 3,000 mg two times per day, may help prevent joint and connective tissue breakdown.

Herbs – Natural Remedies For Lupus

Herbs are generally available as standardized, dried extracts (pills, capsules, or tablets), teas, or tinctures/liquid extracts (alcohol extraction, unless otherwise noted). Mix liquid extracts with favorite beverage. Dose for teas is 1 – 2 heaping teaspoonfuls per cup of water steeped for 10 – 15 minutes (roots need longer).

Astragalus (Astragalus membranaceus) appeared to reduce overactive immune function in people with lupus in one study. However, the study was preliminary; more research is needed to know whether astragalus works. Do not take astragalus without talking to your doctor first, especially if you already take medications to suppress your immune system.

Tripterygium wilfordii, 30 – 45 mg daily, a Chinese herb. You may also prepare teas from the root of this herb. Two preliminary studies suggest that this herb may help suppress the immune system and reduce joint pain and inflammation. However, not much is known about its safety, and one report suggests that using it long-term may reduce bone density in women. Low bone density is a risk factor for osteoporosis. There are other reports of possibly more serious side effects. Do not take this herb without your doctor’ s supervision. Do not take tripterygium if you are pregnant.

People with lupus should avoid alfalfa supplements, and should talk to their doctor before taking any herb that is used to strengthen the immune system, such as echinacea or gingko.

Homeopathy

Few studies have examined the effectiveness of specific homeopathic remedies. Professional homeopaths, however, may recommend one or more of the following treatments for lupus based on their knowledge and clinical experience. Before prescribing a remedy, homeopaths take into account a person’s constitutional type – your physical, emotional, and intellectual makeup. An experienced homeopath assesses all of these factors when determining the most appropriate remedy for a particular individual.

Apis mellifica
Arsenicum album
Calcarea carbonica
Causticum
Rhus toxicodendron
Ruta graveolens
Thuja occidentalis
Acute dose is 3 – 5 pellets of 12X to 30C every 1 – 4 hours until symptoms are relieved.

Prognosis/Possible Complications :

The prognosis for people with lupus is mixed. Half of people who go into remission stay in remission for decades, but 90% of people with lupus have complications. For women, symptoms tend to get better after menopause. 90% of people with lupus have a survival rate of 10 years, and 63 – 75% have a survival rate of 20 years. People with certain complications from lupus tend to have a poor prognosis.

Follow Up :

Your doctor should monitor you closely during a flare to make sure you get the right treatment, and should watch your condition long-term to spot any complications with your lungs, kidneys, or other organs.

Lupus Procedure Rules

August 9th, 2011 No comments

Lupus Treatment Guidelines

What is Systemic Lupus Erythemathosus? You could read that on my previous article What is Lupus. We could divide the Lupus Procedure into Non-Pharmacological and Pharmacological in shorts Non-Drugs and Drugs. We will certainly review Lupus treatment into 2 parts. In this section we will certainly go over on the Non-Pharmacological Treatment.

Non-Pharmacological Lupus Procedure comprises of

1. Academic training

Person education and learning plays an essential part since Systemic Lupus Erythemathosus is a persistent disease. Patients should be geared up with adequate info about an assortment of medical manifestations that can take place, the extent of the illness is differ, so people could recognize and decrease too much anxiety. It is essential to females of reproductive age to provide the understanding that if they want to obtain expectant, after that the pregnancy must be prepared when the illness is in remission, so it could decrease the incidence of flare and the threat of abnormalities in the unborn child in addition to patients during pregnancy.

2. Social and Psychological Assistance

This can come from physicians, family, buddies and includes peer group or support group among lupus patients. The team could conduct clients and public education and also can give advocacy and support for Lupus clients. There are a great deal of lupus team or organization, you can locate it on the internet.

3. Relax

Patients with Systemic Lupus Erythemathosus frequently experience tiredness that it needs sufficient rest, along with take into consideration other reasons such as fibromyalgia, hypothyroidism and/or misery. You could review my prevoius blog post on Lupus Symptoms for even more info on fatigue reasons.

4. Sun screen lotion

In clients with Systemic Lupus Erythemathosus ailment activity could be raised after exposure to sunshine, so it is strongly advised to stay clear of excessive sun direct exposure and use sun screen lotion with SPF> )30 in 30-60 minutes before exposure, every 4-6 hrs.

5. Screen closely

Clients with Systemic Lupus Erythemathosus vulnerable to infection and should look out if there is unexplained fever source. The danger of infection likewise enhanced in addition to the administration of drugs and corticosteroids immunosupression. Danger of incident heart disease events, weakening of bones and malignancy additionally increased in clients with SLE, so the need to regulate threat aspects resemble cigarette smoking, excessive weight, dyslipidemia and hypertension is a must.

On the upcoming part of Lupus procedures, we will discuss regarding Pharmacological lupus therapy.

.

Pharmacological Procedure of SLE

Immunomodulatory treatment

1. Cyclophosphamide.

2. Mycophenolate mofetil (MMF).

3. Azathioprine.

4. Leflunomide (Arava).

5. Methotrexate.

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Treatment Plan

There is no recognized remedy for lupus. However, your team of health care suppliers can develop a treatment plan to prevent flare-ups, to address them when they do occur, and to minimize problems.

Prevention

While you could’ t protect against lupus, you can assist protect against flare-ups:.

Avoid sunlight exposure, high-dose birth control pills, penicillin, and sulfonamides (anti-bacterial representatives).
Exer.cise regularly
Get flu and pneumonia vaccines

Systemic Lupus Erythematosus Symptoms

August 4th, 2011 No comments

Wide spread Lupus Erythematosus Manifestations – Systemic lupus symptoms

juvenile-systemic-lupus-erythematosus-symptoms

SLE influences multiple organ devices. The Systemic Lupus Erythematosus Manifestationsadvancement is visible by remissions and regressions and could vary from moderate to intense.

Mucocutaneous – A lot of people have skin lesions at some time during the advancement of the condition. Butterfly breakout, erythema or redness over the cheeks and nose, saving the nasolabial layers, which shows up after sunlight exposure is the most usual lesion. It usually persists however lasts a few days. Some people will certainly get discoid sores, that are more inflammatory and have a scarring propensity. Alopecia or baldness is common, yet thinning hair is unheard of.

Arthritis – Joint Systemic Lupus Erythematosus Manifestationswhich are often the earliest indication take place in over 90 % of people at time throughout the health problem. Just a few joints are typically had an effect on, specifically those of the hands. The SLE arthritis has the tendency to be strolling and in proportion. The arthritis is relatively uncomfortable, and hardly ever warping.
12 to 45 percent of clients have dental and/or nasal ulcers, usually pain-free, unlike herpetic chancre scorchings.

Raynaud sensation – Happened in 16 to 40 % of clients, Chilly or emotion-induced color changes of the figures of the hands and/or feet, the Raynaud phenomenon, is a frequent trouble and might antedate various other attributes of the ailment.

Gastrointestinal tract – Systemic Lupus Erythematosus Symptom is usually included GI tract, but more often from medicine negative effects than from energetic SLE. Instances of the previous consist of gastritis and even peptic ulcers secondary to using NSAIDs alone or in combo with glucocorticoids. SLE vasculitis can bring about pancreatitis, peritonitis, and colitis. Signs of esophageal irritation or reflux could develop. Nonspecific stomach discomfort is regular.

Renal – Systemic Lupus Erythematosus Symptoms of Kidney ended up being clinically obvious in roughly 50 percent of clients; however, most of the continuing to be clients have subclinical ailment that could be demonstrated if renal biopsy were executed. Renal participation normally develops in the first few years of health problem, and should be identified early by routine urinalyses, quantitation of proteinuria, and estimation of the glomerular filtering price (normally by overseeing the plasma creatinine concentration). A number of kinds of glomerulonephritis can take place and renal biopsy serves to determine the type and level of renal involvement.

Cardiovascular – There are a selection of cardio signs of SLE. Pericarditis is rather usual, while verrucous (Libman-Sacks) endocarditis is normally medically quiet however can generate valvular lack and function as a resource of emboli (image 5). Patients with SLE have an enhanced threat of coronary artery condition.

Lung – Pleurisy, pleural effusion, pneumonitis, interstitial lung condition, pulmonary hypertension, and alveolar hemorrhage can all happen in SLE. The threat of thromboembolic involvement is boosted in those with antiphospholipid antibodies. Dyspnea, episodic pleuritic breast pain, dynamic decrease in lung amount in the absence of interstitial fibrosis or substantial pleural ailment recommends the shrinking lung disorder. Pulmonary feature tests are often substantially unusual, with limiting irregularities, before complaints of dyspnea.

Neurologic – Neurologic complications include cognitive defects, organic brain syndromes, delirium, psychosis, seizures, headache, and/or peripheral neuropathies. Other less common problems are movement disorders, cranial neuropathies, myelitis, and meningitis.

Psychosis, which may be due to SLE or to glucocorticoid treatment, is one of several psychiatric manifestations of SLE. Others include: depression, anxiety, and mania.

Neonatal lupus can cause heart block of varying degrees that may be noted in utero and or present as congenital heart block.

Thromboembolic events, often in association with antiphospholipid antibodies, may occur in a substantial minority (20 percent) of patients with SLE. Arterial thromboemboli may cause focal neurologic problems, such as stroke or seizures, and/or more diffuse cognitive defects

Ophthalmologic – The eye is frequently involved in SLE with the most common manifestation being keratoconjunctivitis sicca. rare ophthalmologic manifestations of SLE include: Cotton wool exudates due to retinal vasculitis, Anterior uveitis, Episcleritis or scleritis.

Hematologic– Cytopenias and thrombophilia, an increased the propensity to develop thromboembolic disease, might be features of SLE. Leukopenia which is diagnostically useful is common. While, it is usually not symptomatic unless severe  (less than 2000/mm3). 43 to 66 % of patients have leukocyte count of less than 4500/mm3. Many patients have a mild anemia, which is most often due to the anemia of chronic disease.

Lymphadenopathy and splenomegaly – Many patients have peripheral lymphadenopathy and/or splenomegaly.
Anticardiolipin antibodies can produce a false positive test for syphilis (eg, VDRL).

Immunologic – Autoantibody production is a hallmark of Systemic Lupus Erythematosus Symptoms.

Lupus Symptoms: How to Identify

August 3rd, 2011 No comments

Lupus Symptoms– The best ways to Determine

Symptoms of Lupus

Systemic lupus erythematosus (SLE) is a chronic inflamed problem of unidentified cause that could have an effect on the joints, skin, heart, renal systems, nerves, lungs, serous membranes and/or other organs of the body, therefore, lupus symptoms are differ. SLE is characterized by cells and cell damages from pathogenic autoantibodies and immune complexes. Ninety percent of patients are women in childbearing years and the illness is a lot more common in African Americans. Multiple body organ system indications can take place, including musculoskeletal (arthralgias, myalgias), cutaneous (malar breakout, photosensitivity, hair loss), renal (nephritis, nephritic disorder), stressed (seizures, hassles), cardiopulmonary (pericarditis, pleuritis), hematologic (anemia, leukopenia). Immunologic problems, in particular the generation of a quantity of antinuclear antibodies, are another noteworthy attribute of the disorder. There are many kinds of lupus, Systemic lupus erythematosus which influences different physical body parts is the most typical kind, the others are Subacute Cutaneous lupus erythematosus – generates skin sores on components of the body subjected to the sunlight, Discoid lupus erythematosus – causes a skin rash that doesn’t go away entirely, Drug-induced lupus – could be induced by medications, Neonatal lupus – an uncommon type of lupus that impacts newborn babies.

The medical advancement of Wide spread lupus erythematosus is varied and can be represented by patterns of remissions and lasting or severe relapses. Ladies, primarily in their 20s and 30s, are had an effect on much more frequently than guys.

People with SLE are subject to a lot of symptoms, troubles, as well as inflamed participation that might have an impact on virtually every body organ. The most frequent pattern is a mix of constitutional problems with skin, medium hematologic, serologic involvement, in addition to musculoskeletal. On the other individual hand, a number of people have mainly kidney, hematologic, or central nerve fibers manifestations. The particular pattern that dominates through first couple of years of the disease is likely to control later.

Lupus Symptoms, Constitusional – 50 – 100 % of clients has fever, fatigue, and fat burning. Over 50 percent of lupus symptoms is fever that is believed to be because of active illness. 60 % of the fevers were thought to be due to lupus, 23 % to infection, and 17 % to various other reasons. Threat elements for infection: long-lasting disease damage, neutropenia, hypocomplementemia, lymphopenia, energetic lupus disease, renal participation, neuropsychiatric signs, and using glucocorticoids and other immunosuppressive drugs. A lot of fevers as a result of energetic SLE will certainly transmit with usage of acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), and/or low to medium dosages of corticosteroids, if it does not, the suspicion of a contagious or medicine associated etiology is risen.

Lupus symptoms in women

Low Energy or tiredness happens in 80 – 100 % of lupus symptoms, and often the most debilitating. Its existence in not obviously correlated with other measures of disease activity. Hence fatigue is highly correlated with reduced physical exercise tolerance. However, fatigue might not be caused by active SLE, yet to one or more of the following: depression, increased work load, poor habits (smoking, less active living, substance abuse), stress or anxiety, hypothyroidism, anemia, use of specific medications (such as beta-blockers, prednisone), any inflammatory and/or contagious disease, coexistent fibromyalgia, sleeping disturbances and/or deconditioning, or a perception of inadequate social support. Fatigue caused by SLE may respond to antimalarials and glucocorticoids.Weight gain in lupus is commonly caused by one of two factors: salt and water retention associated with hypoalbuminemia, or increased appetite associated with the use of glucocorticoids.Weight loss often occurs before the diagnosis of SLE. Unwilled weight loss could be because of decreased appetite, the side effects of drugs (especially diuretics or antimalarials), and gastrointestinal disease such as (GERD) gastroesophageal reflux disease, abdominal pain, pancreatitis, or peptic ulcer disease.

Here is a list of Lupus Symptoms 

General Symptoms : Photosensitivity (sensitive to the sun light), Fatigue, Malaise, Hair Loss, Weight gain or loss, Fever
Central Nervous System : Lupus Headaches, Fibromyalgia, CNS Vasculitis
Cardio-Vascular System : Antiphospolipid Syndrome, Anemia, Chest Pain when taking a deep breath, Myocarditis, Endocarditis
Gastrointestinal Tract : Gastroesophageal Reflux Disease, Lupus Hepatitis, Chronic Diarrhoea, Nausea and Vomitting, Ascites
Musculoskletal System : Arthritis, Muscle Pain, Fibromyalgia
Reproductive System : Lesion(s) in genital area, Loss of Libido, Increase Miscarriage rate
Kidney : Lupus Nephritis
Skin : Discoid Lupus Erytemathosus, Malar Rash / Butterfly Rash, Tumid Lupus Erythematosus, Raynaud’s Phenomenon, Lupus Panniculitis, Purpura, Subacute Cutaneus Lupus
Mouth and Nose : Mucosal Discoid Lupus, Mouth and Nose Ulcers, Bullous Systemic Lupus Erythematosus
Lungs : Pleuritis, Shortness of breath, Chest Pain
Other Organs : Eye Problem, Lupus Thyroiditis, Swollen Glands, Rhinitis nonallergica

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How Is Lupus Diagnosed?

Lupus is not diagnosed with single test only. The diagnosis might take several months or years, as your doctor has to piece together the puzzle of symptoms of this complex disease in order to be diagnosed accurately. Knowledge and awareness of  the doctor and also good communication from the patient are important so that the correct diagnosis can be made. Some test for lupus or tools may be required by your doctor to make the diagnosis of lupus, such as :

  • Medical history
  • Complete physical examination
  • Complete blood count (CBC)
  • Blood chemistries
  • Erythrocyte sedimentation rate (ESR)
  • Urinalysis
  • Complement levels
  • Antinuclear antibody test (ANA)
  • Other autoantibody tests (anti-DNA, anti-Sm, anti-RNP, anti-Ro [SSA], anti‑La [SSB])
  • Anticardiolipin antibody test
  • Skin biopsy (looking at skin samples under a microscope)
  • Kidney biopsy (looking at tissue from your kidney under a microscope).
  • X rays and other imaging tests can help doctors see the organs affected lupus

Criteria for classification of SLE
(SLE = 4 or more of these 11 criteria)

  • Malar (butterfly) rash
  • Discoid rash
  • Photosensitivity
  • Arthritis
  • Oraulcers
  • Serositis (pleurisy or pericarditis)
  • Renadisorders (proteinuria or casts)
  • Neurologicadisorders (intractable headache, seizures or psychosis)
  • Haematologicadisorders (haemolytic anaemia, leucopenia, lymphopenia or thrombocytopenia)
  • Immunologicadisorders (positive LE cells, anti-DNA, anti-Sm or false positive syphilis serology)
  • Positive antinuclear antibody

Diagnostic tests

  • ESR—elevated in proportion to disease activity
  • antinuclear antibodies (ANA)—positive in 95% (key test)
  • double stranded DNA antibodies—90% specific for SLE but present in only 60% (key test)
  • rheumatoid factor—positive in 50%
  • LE test—inefficient and not used

The diagnosis cannot be made on blood tests alone. Supportive clinicaevidence is necessary.

Management

Appropriate explanation, support and reassurance, use of sunscreens
Refer to consultant for shared care
Drug treatments

  • mild: NSAIDs (for arthralgia)
  • moderate (esp. skin, joint serosa involved): low-dose antimalarials, e.g.
  • hydroxychloroquine up to 6 mg/kg once daily
  • severe: corticosteroids are the mainstay immunosuppressive drugs, e.g. azathioprine

Avoid drugs in those in clinicaremission and with normacomplement levels
Other treatments such as plasma exchange and immunosuppressive regimens available for severe disease

 

Related Article you might like Lupus symptoms in women, Rheumatoid Arthritis Symptoms and Diagnosis

Recommended Books for Lupus

Rheumatoid Arthritis Diet– The Simple Fact

August 1st, 2011 No comments

Rheumatoid Arthritis Diet regimen

Rheumatoid Arthritis DietThe Simple Reality regarding Rheumatoid Arthritis Diet regimen— For long times, special diet regimens for patients with Rheumatoid Arthritis were delegated to phoniness. It was lately that the Arthritis Structure presented “The Reality regarding Diet regimen and Arthritis,” stating “if there was a partnership in between arthritis and diet, it would have been uncovered long ago. The reality is simple, that there is no clinical proof that any type of diet plan or meals has anything to do with causing arthritis and no evidence that any type of food works in managing or ‘curing’ it.”.

Just how could perhaps diet have a result on arthritis? Initially, some individuals with rheumatic disease might be adverse certain foods and have sign and symptoms that could be a symptom of food allergy. Second, particular kinds of diet plans with specific quantities of protein, calories, and greasy acids may have a result on the immunologically-mediated inflammation that accompanies arthritis.

Exists any Rheumatoid Arthritis Diet plan!.?. !? There is no effective evidence at this moment that any type of diet plan aside from a well balanced, healthy one is constantly beneficial to individuals with Rheumatoid Arthritis. One study of a popular diet regimen (the removal of ingredients, red meat, chemicals, fruit, herbs and spices, dairy items, and liquor) for clients with Rheumatoid Arthritis discovered no consistent salutary outcome on condition activity.

Is Rheumatoid Arthritis signs prompted by meals hypersensitivity in some patients? Physicians and people continue being interested that arthritis might often be the outcome of irritation to meals. As instances: Behçet’s syndrome has been connected with black walnuts; Palindromic rheumatism with sodium nitrate; Systemic Lupus Erythematosus (SLE) with hydrazine and with canavanine in alfalfa (which might cross-react with native DNA or turn on B lymphocytes), and Rheumatoid Arthritis (RA) presumably with many substances featuring smoke, tobacco, home dirt, tartrazine, petrochemicals, wheat or grain, corn, dairy items, and beef. Furthermore, rheumatoid-like synovitis in bunnies has been generated by cows’ milk.

Inflamed arthritis could possibly be connected with foods has actually been confirmed (for picked patients) by complete, potential, placebo-controlled, double-blind researches. One person, as an example, had 30 minutes of morning rigidity, 3 inflamed joints and 9 tender joints on her normal diet. Nearly all of these seekings vanished after a three day quick. After that they can be reproduced by milk challenge yet not with various other foods.

The role of plant or fish oils or diet regimens? Nutritional condition placed a regulation a deep influence on immune cooperation and illness sign. For example, mice with SLE or rodents with arthritis who are fed diets rich in EPA (eicosapentaenoic acid – polyunsaturated fatty acid analog) ended up much better as compared to manage pets.

Clinical tests of plant seed oils and fish oils have shown a modest decrease particularly signs with procedure in people with Rheumatoid Arthritis (RA) but not Systemic Lupus Erythematosus (SLE). Helpful effects of fish oil supplements could be improved by limiting the nutritional usage of polyunsaturated oils (eg, soybean, corn, sunflower) to less compared to 10 grams per day. Nevertheless, fish oil pills are beneficial, the amount of omega 3 had in every capsule is.equal to that found in 1 mL of cod liver oil.

Compared to a typical “Western” diet, a Mediterranean diet in general obtains much less calories from animal fat and more from vegetable oils and cereals, especially olive oil. Liberal consumption of beans and fresh fruits in addition to a small daily consumption of wine. The possible effects of a Mediterranean diet (MD) was the topic of a research in which 51 individuals with Rheumatoid Arthritis (RA) were randomly given to an omnivorous or to a MD cuisine for 12 weeks. There was little change spotted in patient general assessments in the omnivorous subjects nor in their scores of the disease activity. While those patients who ate a MD had more development in some disease activity scores, other indicators were not changed.  Considering that the assessment and intervention were not “blinded”, a considerable placebo effect in the group given to the MD can’t be excluded.

These findings on Rheumatoid Arthritis Diet suggest that dietary components that transform arachidonic acid-derived prostaglandin or leukotriene generation have an effect on immunologic responses and inflammatory and may as a result ameliorate symptoms of rheumatic disorder.

The nutritional supplements’ role? A number of elements, including zinc, copper, and vitamin B, have been documented to be beneficial for individuals with arthritis. Generally, however, the proof in support of such statements is short. For instance, even though copper salts have been anti rheumatic in clinical trials, many adverse effects were associated with the usage, consequently, copper salts have not progressed as an important therapeutic agent. In a different study, some patients with Rheumatoid Arthritis benefited from oral zinc, however, the improvement was inconsistent and modest, and there was no confirmation in other studies. Additionally, although the administration of L-histidine has aided a small set of Rheumatoid Arthritis patients, it has not blossomed as an important agent. There is also lack of evidence to support the efficacy of vitamin C for arthritis patients.

Whilst vitamin B6 concentrations are reduced in the serum of patients with Rheumatoid Arthritis and levels of the active metabolite of Vit B6 (pyridoxal 5′ phosphate), are inversely correlated with disease activity, there is currently no convincing evidence on Vitamin B6 supplementation in the diet has any valuable effect on associated disorders or disease activity.

RHEUMATOID ARTHRITIS THERAPIES

May 27th, 2011 No comments

RHEUMATOID ARTHRITIS TREATMENTS

rheumatoid arthritis treatment algorithmRheumatoid arthritis procedures take part in a necessary duty in controlling the irritation of the condition and lessening joint destruction. The procedure integrates a mix of medicine treatment and other individual non-drug therapies, and sometimes it include surgical treatment. The procedure of Rheumatoid Arthritis Symptoms should be personalized to each client’s particular instance, that includes the seriousness of the ailment, the negative effects and the effectiveness of particular therapies.

The therapies variety may be various for an individual with RA who has other individual illnesses, such as liver or renal systems ailment. In order to make an efficient and acceptable plan for managing rheumatoid arthritis, it is essential to collaborate with a healthcare carrier.

RHEUMATOID ARTHRITIS THERAPY – GENERAL BASICS

The function of rheumatoid arthritis treatment is to manage a person’s signs and symptoms, to prevent joint damage, and to keep high quality of life and ability to feature of the client. The preliminary therapy of RA intends to minimize or to get rid of swelling. Lots of drugs for managing rheumatoid arthritis have possibly major negative side effects. Physicians Typically prescribe medications with the least negative effects initially, or the threat of side effects from therapy must be considered versus the advantages.

Long-lasting healthcare with routinly planned gos to is important for the effective procedure of rheumatoid arthritis. This treatment incorporates medical gos to and examinations to examine the effectiveness of treatment and check for negative side effects.

Nonpharmacologic therapies are treatments other than medications and are the fundamental foundation of procedure for all person suffering RA. There are a vast assortment of non-medication treatments offered.

Education and learning and advising can help you to much better comprehend the quality of rheumatoid arthritis and take care of the challenges of this condition.

Biofeedback and Cognitive Behavioural Therapymight assist powerful Rheumatoid Arthritis symptoms.

Relax – Swollen joints need to be relaxed, as fatigue is a common symptom of rheumatoid arthritis yet physical fitness must be maintained. If joint discomfort or minimal joint movement disrupts working out, the physical and physical therapists must be searched for assistance with health and fitness curricula,.

Workout is important as stagnation could cause a loss of joint motion, contractions, and a loss of muscle strength. Person with rheumatoid arthritis oftens become less active as the ache and rigidity prompted. Therefore, weakness decreases joint security and boosts weary over the time.

Physical therapy could minimize pain, assistance maintain joint structure and function and lessen irritation for clients with RA. Certain types of bodily treatment are accustomed to attend to particular results of RA such as the application of heat or cool to reduce pain or stiffness, an assessment with a podiatrist that could make foo.t orthotics (equipments that make sure correct position of the foot) and supportive footwear. Reduce inflammation of the sheaths surrounding tendons (tenosynovitis) by Ultrasound.

Nutrition and dietary therapy – Dietary therapy helps to make sure that the patient eat a sufficient amount of calories and nutrients. Weight reduction might be advised for over weight and obese people to minimise pressure on swollen joints. Persons with rheumatoid arthritis possess a higher risk of getting coronary artery disease. Hypercholesterolaemia is one risk factor for coronary disease that can respond to modifications in diet. Arthritis pain and joint swelling have been modestly improved by fish oils and some plant oils, such as borage seed oil. However, there is no diet that can cure rheumatoid arthritis, neither herbal nor nutritional supplements, such as collagen or cartilage; these treatments can be harmful and are not generally recommended.

Smoking and alcohol – Studies have shown that smoking is a risk factor for rheumatoid arthritis and smoking cessation can improve disease. Smokers need to quit totally. Moderation of alcohol consumption is not hazardous to rheumatoid arthritis, event hough it might rise the chance of liver destruction from some drugs such as methotrexate.

Measures to minimise bone loss – Rheumatoid arthritis causes bone loss, that can lead to osteoporosis. The likelihood of bone loss is increase in persons who are inactive, and persons who are taking glucocorticoids, such as prednisone.